[elklindo69]

This is why properly designed scientific studies are required to establish the safety and efficacy of the drugs we take not the quackery that Trump and the right wing blogosphere is promoting.



A small Brazilian study on the effects of the anti-malaria drug chloroquine, which is similar to the drug that President Trump has touted as a possible "game changer" in treating the coronavirus, was abruptly halted because some patients taking high doses developed irregular heart rates generating "safety hazards."

The findings were revealed in a study funded by the Brazilian state of Amazonas and published on Saturday in medRxiv, an online server for medical articles, The New York Times first reported.

Chloroquine is similar to hydroxychloroquine, the drug Trump has repeatedly touted. Health experts have insisted that not enough is known about either drug to determine its efficacy in combating COVID-19.

The Brazilian study included 81 hospitalized patients, with about half being given a dose of 50 milligrams of chloroquine twice daily for five days. The other participants were prescribed a dose of 600 milligrams for 10 days.

Patients taking higher doses experienced heart arrhythmias, or improper beating of the heart, within three days, according to the study. Eleven patients died by the sixth day of treatment and caused the research on high-dosages to end.

"Preliminary findings suggest that the higher CQ dosage (10-day regimen) should not be recommended for COVID-19 treatment because of its potential safety hazards," the study's abstract said. "Such results forced us to prematurely halt patient recruitment to this arm."

The lower-dosage portion of the study did not include enough patients to gauge whether it is effective in treating severely ill patients, the Times noted. The researchers said that more studies assessing the efficacy of chloroquine are "urgently needed."

The researchers said that the study would prove useful given the global push to use anti-malaria drugs to treat COVID-19, providing "updated COVID-19 patient management recommendations." The study was published in medRxiv before being peer-reviewed, the Times noted.

There is no known cure for COVID-19. While Trump and some of his allies have repeatedly promoted the use of hydroxychloroquine, health experts such as Anthony Fauci, the government's top infectious disease expert, warn that there isn't enough data to show if it works.

[RealJustme]

A small Brazilian study

[Clownkicker]

ALL the studies being run are small, dimwit.

If the study had come out favorably for HCQ, you wouldn't be laughing at the size of the study, would you. You would be here saying how it proved beyond any doubt that Trump was right. But you'll never admit that he was terribly wrong in prescribing untested medications without a license.

But you're one of those imbeciles calling for the stuff to be released because "what have you got to lose?"

You shouldn't give a damn one way or the other about the size of a study you think is totally unnecessary.

[RealJustme]

he was terribly wrong in prescribing untested medications without a license.

Clown once again depends on fake news for his information. Name one person Trump has prescribed the drug to...waiting.

[johnforbes]

As with any drug, you want to dose properly.

HCQ has been around for 66 years and is generally quite safe.

There are some side-effects for any drug.

For example, the Stupidity Pill which Elkin takes daily makes him partisan and stupid.

The fact that Elkin even posted this thread shows the desire of the Left to NOT try to cure this virus.

[Clownkicker]

"Name one person Trump has prescribed the drug to...waiting."-RealTool

He prescribed it to YOU, dimwit.

He also prescribed it to millions of others who listened to his news conference on April 4th at 5:16 p.m. ET

You really need to listen to the dangerous things Trump says, Tool. You'll be shocked if you ever do..... assuming you understand the English, of course.

[RealJustme]

He prescribed it to YOU, dimwit

No he didn't.

[Clownkicker]

You may be right, dimwit.

Since you understandably never watch Trump's enervating news conferences you are probably still ignorant of his prescription order. "Take it. [HCQ]"-Donald Trump

I told you where to find it, Tool. Go look, if you dare to find out how criminal your God is.

[sillydaddy]

"... was abruptly halted because some patients taking high doses developed irregular heart rates generating "safety hazards."

HIGH DOSES???
Everyone knows you have to start with small doses, one per week to see if the patient will tolerate it...
and it is always kept at one dose per week even for those who have been taking it for years …!

[Clownkicker]

^^^^^^^ Now THAT is the dumbest person on the internet. And he's a diehard Trump supporter. (Emphasis on the "die" part.)

[elklindo69]

In the study there were two groups of subjects:

#1) received 600mg dosage twice per day for 10 days.
#2) recieved 450mg dosage twice per day on the 1st day then 450mg once a day for the remaining 4 days.

#1) 16 out of 41 died
#2) 6 out of 40 died

So obviously there were safety concerns which prompted the researchers to terminate the study early. They said to not use the high doasge and there are obviously concerns that the lower dosage has risks as well. And they will have to perform additional studies to determine the risk profile.

The dosing for patients with malaria is as follows:

Adults—
Standard dosing: At first, 800 milligrams (mg) (4 tablets) taken as a single dose. Then, 400 mg taken 6 hours, 24 hours, and 48 hours after the first dose.
Weight-based dosing: Dose is based on body weight and must be determined by your doctor. At first, 13 milligram (mg) per kilogram (kg) of body weight taken as a single dose. Then, 6.5 mg per kg of body weight taken 6 hours, 24 hours, and 48 hours after the first dose. However, dose is usually not more than 800 mg for the first dose and not more than 400 mg for the next doses.

https://www.mayoclinic.org/drugs-supple ... g-20064216

And this is not much different than the recommended dosing for the treatment of people who have malaria.

Now it appears that the people who were in the higher dosage regiment experienced more heart issues than the people in the lower dosage regiment. And it raised enough red flags with the researchers to terminate the study.

I imagine that if this study results are repeatable in independent studies then they will probably will not use it any longer....

[elklindo69]

A small Brazilian study

Of course it was small. It was a safety study.

22 out of the 81 subjects died. What do think would have happened if they used thousands of people dimwit?

I'm dealing with fucking morons here...............

[elklindo69]

As with any drug, you want to dose properly.

HCQ has been around for 66 years and is generally quite safe.

There are some side-effects for any drug.

For example, the Stupidity Pill which Elkin takes daily makes him partisan and stupid.

The fact that Elkin even posted this thread shows the desire of the Left to NOT try to cure this virus.

No dummy it's not generally quite safe as the study has proven....they determined the side effects were so detrimental that the study had to be terminated. 22 out of the 81 subjects died.

Maybe you should pull your partisan head out of your ass for once.

[johnforbes]

That was not the reason.

Looking at NY data, coronavirus killed few without an underlying problem.

Key to reopening might be geographic differences plus urging elderly, obese, diabetics to continue self-quarantine?

[elklindo69]

So then why did the Brazilians halt the study?

[johnforbes]

Elkin, stop rooting for HCQ to fail.

Instead, any sane human would wish for HCQ, or something, to help prevent people from dying.

Didier Raoult, MD, PhD has had three thousand (3000) peer-reviewed articles published.

In his recent work on over 1000 coronavirus patients, his ultimate cure rate with HCQ and AZ was 98 percent, with a mortality rate of just 0.5 percent with elderly.

[RealJustme]

Why are liberals all against allowing patients dying the opportunity to try HCQ ?

[johnforbes]

One key to HCQ is apparently early enough use of it.

If you have a patient who is elderly, obese, or diabetic, and the person doesn't get HCQ soon enough, then certainly you could have a problem.

Elkin raised the topic of the Brazil study, so it would be up to him to explain the study group and the circumstances....if he is honest, that is.

[Clownkicker]

"Elkin, stop rooting for HCQ to fail.
Instead, any sane human would wish for HCQ, or something, to help prevent people from dying."-johnflubs

No, johnny, any sane human doesn't base their medical responses to disease on what they "wish" would be true.
Sane humans gather data and draw conclusions from those data in a rational manner. Trump supporters don't do that.
You are a prime example of the Trump supporter who "wishes" that the world were safe to behave just as they always behaved, but it isn't.

You have been scoffing at things like the phrase "exponential growth" when medical people warn you of the danger. But your scoffing and wishing doesn't make the reality go away. The growth IS exponential right now, regardless of what Trump is telling gullible people like you in order to stop your panic and get you to shrug off and scoff at scientific experts.

After the first official COVID-19 case in the U.S. it took 38 days to reach 10,000 dead. You scoffed and say it's no worse that the flu.
It then took NINE more days to reach 30,000 dead, even with social distancing measures in place. You still pretend there is no "exponential growth" in the pandemic. Then it took TWO more days for nearly 5,000 more to die, and you are still here scoffing and wishing and wanting to go back to the previous normal behaviors.

You just don't get it. This pandemic follows the biological laws of pandemics. You can't escape that reality without a vaccine or social distancing. All your wishing isn't going to change it. Meanwhile, elklindo and I will be looking for data and facts to inform our political views of this pandemic. Trump supporters will be listening to a clown who doesn't even vaguely comprehend what we are facing, and someone who, if it is left up to him, will lead us into a national disaster of proportions even you won't be able to avoid or scoff at any longer.

[johnforbes]

I was right.

There was no "exponential" growth in the math sense.

Dolts on TV were just babbling.

Who was closer to being right, Ferguson the expert at Imperial College who estimated 2.2 million dead in America, or me who suspected a mortality rate appropriate for a bad flu season?

Sadly, it was me.

[elklindo69]

So Johnnie....why did the Brazilians halt the hydroxychloroquine study?

And why has Trump gone silent on the hydroxychloroquine study?

[johnforbes]

You mentioned it, Elkin, so you should provide any data.

The fact is that HCQ is being used all over America and it apparently works.

You should be happy about that, but your hatred of Trump is so extreme that you actually want sick people NOT to be helped by a cheap old drug Trump mentioned considering.

Meanwhile, Elkin, you started a thread on another drug which is unproven but expensive.

[elklindo69]

You mentioned it, Elkin, so you should provide any data.

https://www.reuters.com/article/uk-fact ... SKBN21Z395

[Clownkicker]

"You mentioned it, Elkin, so you should provide any data."-johnjhypocrite

^^^^ This from the hypocritical asshole who NEVER provides any evidence to back up his assertions.

NEVER.

Instead, he says "You're capable of researching it yourself." or "I'm not your teacher." or some other really asshole thing to say.

But when HE wants an answer he blames it on the other guy. What a fucking intellectually impotent asshole.

[johnforbes]

I always post correct things, but do not do the homework of lazy students like Clownslacker.

Elkin posted about the Brazilian study, so he should wax diligent on the Brazilian.

[Clownkicker]

No, he shouldn't, johnny, not for you he shouldn't. He doesn't need to do your homework for you.

You deserve nothing in the way of evidence to back up someone else's assertions. You deserve exactly what you provide to back up your assertions, which is bupkis.